ISSN : 2488-8648
International Journal of Basic Science and Technology
A publication of the Faculty of Science, Federal University Otuoke, Bayelsa State
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ISSN : 2488-8648
Home About IJBST For Authors Issues Useful Downloads Contact
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×published date:2016-Dec-14
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Abstract
Prostate cancer (PCa) is the most common male-specific cancer worldwide. More often, PCa is diagnosed early. With the slow development of some PCa cases, there is a wide window of opportunity for chemoprevention. Chemoprevention is intended to improve the quality of life, reduce morbidity and mortality in patients. Based on epidemiological studies, it is believed that dietary agents that are utilised specifically in a part of the world may be related to its low disease incidence profile. Healthier diets in Asia contain high levels of curcumin, diindolylmethane (DIM) and epigallocathechin-gallate (EGCG). These diet-derived agents may be responsible for the much lower cancer incidences in Asia. Our aim is to utilise cell models of PCa (LNCaP cell lines) and investigate the effect of curcumin, DIM, EGCG and their paired combinations on cellular growth and survival through the cell proliferation analysis, ATP and Clonogenic assays. Results from cell proliferation analysis showed significant time-dependent growth inhibition following treatment with curcumin, DIM, EGCG and their paired combinations respectively (P < 0.0001). However the paired combination of these diet-derived agents: curcumin and DIM (C+D), curcumin and EGCG (C+E) and, DIM and EGCG (D+E) did indicate enhanced inhibition to LNCaP cells viability and growth. Further studies need to be conducted for paired combinations of notable diet-derived agents as they may possess improved chemoprevention abilities in dealing with the progression of PCa.
Keywords: curcumin, DIM, EGCG, LNCaP chemoprevention,
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