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×published date:2015-Oct-30
FULL TEXT in - | page 31-34
Abstract
Pregnancy induces extensive physiological changes in the haematological and haemostatic systems at the different trimesters. This is to accommodate the demands for foetal growth and development. To ascertain the changes in blood coagulation parameters in pregnancy, blood samples were randomly collected from 100 pregnant women in the three different trimesters who were attending the antenatal clinic at the University of Benin Teaching Hospital (UBTH), Benin City. The samples were analyzed for prothrombin time (PT), platelet concentration (PLT), activated partial thromboplastin time (APTT), haemoglobin concentration (HGB), white blood cell count (WBC) and packed cell volume or haematocrit (PCV or HCT). The values obtained were compared with the values in 50 non - pregnant women (control). The PT of 18.37 ± 0.3 seconds in pregnant women was significantly higher than 14.14 ± 0.2 seconds obtained in the control (p < 0.05). The PCV of 29.33 ± 0.3% obtained for pregnant women was significantly lower than 35.07 ± 0.2% in the control (p < 0.05) indicating a decrease in the PCV of pregnant women. Also, the APTT of 45.48 ± 1.1seconds obtained from pregnant women was of no significance compared to 42.02 ± 0.3 seconds from the control (p > 0.05). Platelet concentration of 129.02 ± 3.5 x 109/L (pregnant women) was significantly lower than 175.10 ± 2.9×109/L (nonpregnant women). The results showed that the subjects had features of a hyper-coagulation state that might have been triggered by body immune reactions arising from low concentrations of most blood components and an increase in blood coagulation factors.
Keywords: Benin city, Blood, Coagulation parameters, Pregnancy, Trimester
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