ISSN : 2488-8648
International Journal of Basic Science and Technology
A publication of the Faculty of Science, Federal University Otuoke, Bayelsa State
Home About IJBST For Authors Issues Useful Downloads Contact
ISSN : 2488-8648
Home About IJBST For Authors Issues Useful Downloads Contact
Questions are asked and these questions need answers. This is the reason why this page is created to enable us share few worries!
×published date:2022-Nov-22
FULL TEXT in - 
| page 192 -199
Abstract
Changes in plasma bilirubin and protein concentrations of paracetamol-overdosed albino rabbits were studied using standard methods. Twenty-one albino rabbits were allotted into seven groups (A-G) of three animals each. Groups A, B, and C were administered distilled water (20ml/kg body weight), coconut water (20ml/kg body weight), and paracetamol (1000mg/kg body weight) orally for 7 days respectively. Groups D and E were administered coconut water and silymarin (35mg/kg body weight) for 6 days and paracetamol on the 7th day, while Groups F and G were given distilled water for 6 days, paracetamol on the 7th day and coconut water and silymarin after 3 hours respectively. Results show that paracetamol administration significantly (P<0.05) reduced the animal's body weight and plasma total protein concentration but increased (P<0.05) the bilirubin concentrations. Post-treatment with coconut water and silymarin had a better ameliorative effect than pre-treatment on the changes in the total protein and bilirubin concentrations of the animals overdosed with paracetamol. The results indicate that the effect of paracetamol overdose can be effectively ameliorated with coconut water administration
Keywords: Coconut water, Paracetamol, Overdose, Bilirubin, Silymarin
Bantawa, P. and Rai, R. (2009). Studies on ethnomedicinal plants used by traditional practitioners, Jhankri; Bijuwa and Phedangma in Darjeeling Himalaya.Natural Product Radiance.8: 537-541.
Biplab, D., Sabita, P. D., Bhattacharjee, P. R. and Goswami, B. B. (2002). Coconut: The tree of life. Ind. J. Pharm. Educ.16: 23-30.
Gini, C.K., Muraleedhara, G.K., 2010. Hepatoprotective effect of Spirulina lonar on paracetamol induced liver damage in rats. Asian J. Exp. Biol. Sci. 1, 614–623.
Handa, S.S., Sharma, A. and Chakraborty, K.K. (1989).Natural products and plants as liver protecting drugs.Fitoterapia.57: 307.
Handa, S.S., Sharma, A. and Chakraborty, K.K. (1989).Natural products and plants as liver protecting drugs.Fitoterapia.57: 307.
Jendrassik, L. and Grof, P., (1938). A colorimetric method for the determination of direct and total bilirubin.Biol. Chem.297: 81
Kanchana, N., Mohamed, A.S. (2011). Hepatoprotective effect of Plumbagozeylanica on paracetamol induced liver toxicity in rats. Int. J. Pharm. Pharm. Sci.3: 151-154.
Kanchana, N., Mohamed, A.S. (2011). Hepatoprotective effect of Plumbagozeylanica on paracetamol induced liver toxicity in rats. Int. J. Pharm. Pharm. Sci.3: 151-154.
Leckridge, B. (2004). The future of complementary and alternative medicine—models of integration. The Journal of Alternative & Complementary Medicine, 10(2), 413-416.
Morazzoni, P. and Bombardelli, E. (1995)..Silybummarianum Carduusmarianus).Fitoterapia. 66: 3-42.
Morton, J. F. (1988). Notes on distribution, propagation and products of borassus palms (Arecaceae). Econ. Bot.42: 420-441.
Oloyede, O.B. and Sunmonu, T.O. (2009). Potassium bromate content of selected bread samples in Ilorin, Central Nigeria and its effect on some enzymes of rat liver and kidney. Food Chem. Toxicol.47: 2067-2070.
Rui, Y.C. (1991). Advances in pharmacological studies of silymarin.Mem. Inst. Oswaldo Cruz86: 79-86.
Sabiu, S., Wudil, A.M. and Sunmonu, T.O. (2014). Combined administration of Telfairaoccidentalis and Vernoniaamygdalina leaf powders ameliorates garlic-induced hepatotoxicity in Wistar rats. Pharmacologia. 5: 191-198.
Tong, S., Chu, C., Wei, Y., Wang, L., Gao, X., Xu, X. and Yu, J., (2011). Preparation and effects of 2,3-dehydrosilymarin, a promising and potent antioxidant and free radical scavenger. J. Pharm. Pharmacol.63: 238-244.
Wolf, A., Diez-Fernadez, C., Trendelenburg, C.F., Prieto, P., Hary, S. and Trammer, W.E. (1997).Paracetamol induced oxidative stress in rat hepatocytes. J. Pharmacol. Exp. Ther.280: 1328-1334.
FULL TEXT in - | page 192 -199
Issue 2-Apr-Jun
Issue 1-Jan-Mar
Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 2-Apr-Jun
Issue 1-Jan-Mar
Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 2-Apr-Jun
Issue 1-Jan-Mar
Issue 4-Oct-Dec
Issue 2-Apr-Jun
Issue 1-Jan-Mar
Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 4-Oct-Dec
Issue 2-Apr-Jun
Issue 1-Jan-Mar
Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 2-Apr-Jun
Issue 4-Oct-Dec
Issue 1-Jan-Mar
Copyright © International Journal of Basic Science and Technology | Faculty of Science, Federal University Otuoke 2019. All Rights Reserved.
P.M.B. 126, Yenagoa. Bayelsa state Nigeria
Get the most recent updates
and be updated your self...