ISSN : 2488-8648
International Journal of Basic Science and Technology
A publication of the Faculty of Science, Federal University Otuoke, Bayelsa State
Home About IJBST For Authors Issues Useful Downloads Contact
ISSN : 2488-8648
Home About IJBST For Authors Issues Useful Downloads Contact
Questions are asked and these questions need answers. This is the reason why this page is created to enable us share few worries!
×published date:2015-Oct-30
FULL TEXT in - 
| page 31-34
Abstract
Pregnancy induces extensive physiological changes in the haematological and haemostatic systems at the different trimesters. This is to accommodate the demands for foetal growth and development. To ascertain the changes in blood coagulation parameters in pregnancy, blood samples were randomly collected from 100 pregnant women in the three different trimesters who were attending the antenatal clinic at the University of Benin Teaching Hospital (UBTH), Benin City. The samples were analyzed for prothrombin time (PT), platelet concentration (PLT), activated partial thromboplastin time (APTT), haemoglobin concentration (HGB), white blood cell count (WBC) and packed cell volume or haematocrit (PCV or HCT). The values obtained were compared with the values in 50 non - pregnant women (control). The PT of 18.37 ± 0.3 seconds in pregnant women was significantly higher than 14.14 ± 0.2 seconds obtained in the control (p < 0.05). The PCV of 29.33 ± 0.3% obtained for pregnant women was significantly lower than 35.07 ± 0.2% in the control (p < 0.05) indicating a decrease in the PCV of pregnant women. Also, the APTT of 45.48 ± 1.1seconds obtained from pregnant women was of no significance compared to 42.02 ± 0.3 seconds from the control (p > 0.05). Platelet concentration of 129.02 ± 3.5 x 109/L (pregnant women) was significantly lower than 175.10 ± 2.9×109/L (nonpregnant women). The results showed that the subjects had features of a hyper-coagulation state that might have been triggered by body immune reactions arising from low concentrations of most blood components and an increase in blood coagulation factors.
Keywords: Benin city, Blood, Coagulation parameters, Pregnancy, Trimester
Allen, L. H. (2007). Anemia and iron deficiency: Effects on pregnancy outcome. American Journal of Clinical Nutrition 7 (5): 1280–1284.
Akinbami, A. A., Ajibola, S. O., Rabiu, K. A., Adewunmi, A. A., Dosunmu, A. O., Adediran, A., Osunkalu, V. O., Osikomaiya, B. I. and Ismail, K. A. (2013). Hematological profile of normal pregnant women in Lagos, Nigeria. International Journal of Women’ Health 3 (5): 227-232.
Akingbola, T. S., Adewole, I. F., Adesina, O. A., Afolabi, K. A., Fehintola, F. A., Bamgboye, E. A., Aken'ova, Y. A., Shokunbi, W. A., Anwo, J. A. and Nwegbu, M. M. (2006).Haematological profile of healthy pregnant women in Ibadan, south-western Nigeria. Nigerian Journal of Obstetrics and Gynaecology 26 (8): 763–769.
Bijoy, S. S., Sisir, K. C., Hanes, G. T. and Partha, S. S. (1999). Obstetrics for Post graduates & Practitioners. Aspects of Fetal and Maternal Medicine.1st Edition. Churchill Livingstone. Philadelphia. Pp. 4-10. Boehlen, F., Hohlfeld, P., Extermann, P., Perneger, T.V. and Moerloose, P. (2000). Platelet count at term pregnancy: a reappraisal of the threshold. Obstetrics and Gynecology 95: 29– 33.
Bremme, K. A. (2003). Haemostatic changes in pregnancy. Best Practice and Research in Clinical Obstetrics and Haematology 16: 153-168.
Buseri, F. I., Jeremiah, Z. A. and Kalio, F. G. (2008). Influence of Pregnancy and Gestation Period on some Coagulation Parameters among Nigerian Antenatal Women. Research Journal of Medical Science 2 (6): 275-281. Cerneca, F., Ricci, G. and Simeone, R. (1997).Coagulation and fibrinolysis changes in normal pregnancy. European Journal of Obstetrics, Gynecology and Reproductive Biology 73 (1):31-36.
Cheesbrough, M. (2000). District Laboratory Practice in Tropical Countries, Part 2.Low Price Edition. Cambridge University Press. Cambridge. Pp. 310-323.
Dacie, J. W. and Lewis, S. M. (2006). Practical Haematology, 10th ed., Churchill Livingstone. Philadelphia. Pp. 13-18.
Hellgren M. (2003). Haemostasis during normal pregnancy and puerperium. Seminar on Thrombosis and Haemostasis 29 (2): 125- 130.
Hui, C. and Lili, M. (2012). Changes in coagulation and hemodynamics during pregnancy: a prospective longitudinal study of 58 cases. Archives of Gynecology and Obstetrics 285 (5): 1231-1236.
James, A. H., Bushnell, C. D., Jamison, M. G. and Myers, E. R. (2005).Incidence and risk factors for stroke in pregnancy and the puerperium. Obstetrics and Gynecology 106: 509–516.
John, B. (2009). Haematological problems and Coagulation disorders in Pregnancy. Journal of Clinical Pathology 10: 35-41.
O’Riordan, M. N. and Higgins, J. R. (2003). Haemostasis in normal and abnormal pregnancy. Best Practice and Research in Clinical Obstetrics and Gynaecology 17: 385–396.
Onwukeme, K. E., Uguru, V. E. (1999). Haematological values in pregnancy in Jos. West African Journal of Medicine 9 (2): 70–75.
Pal, B., Szecsi, M., Jorgensen, A. K., Malene, R. A., Nina, P. C. and Steen, S. (2010). Haemostatic reference intervals in pregnancy. Thrombosis and Haemostasis 103 (4): 718-727.
Philip J.D. (2012). Clinical Gynecologic Oncology. Philadelphia: Lippincott Williams & Wilkins. 708 pp. Shen, C., Jiang, Y. M., Shi, H. (2010). A prospective, sequential and longitudinal study of haematological profile during normal pregnancy in Chinese women. Journal of Obstetrics and Gynaecology 30 (4): 357–361. Surabhi, C., Anil, K. T., Sanjay, M., Mohammad, A., and Arvind, K. V. (2012). Physiological Changes in Hematological Parameters during Pregnancy. Indian Journal of Hematology and Blood Transfusion 28 (3): 144–146.
FULL TEXT in - | page 31-34
Issue 2-Apr-Jun
Issue 1-Jan-Mar
Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 2-Apr-Jun
Issue 1-Jan-Mar
Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 2-Apr-Jun
Issue 1-Jan-Mar
Issue 4-Oct-Dec
Issue 2-Apr-Jun
Issue 1-Jan-Mar
Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 4-Oct-Dec
Issue 2-Apr-Jun
Issue 1-Jan-Mar
Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 2-Apr-Jun
Issue 4-Oct-Dec
Issue 1-Jan-Mar
Copyright © International Journal of Basic Science and Technology | Faculty of Science, Federal University Otuoke 2019. All Rights Reserved.
P.M.B. 126, Yenagoa. Bayelsa state Nigeria
Get the most recent updates
and be updated your self...