ISSN : 2488-8648


International Journal of Basic Science and Technology

A publication of the Faculty of Science, Federal University Otuoke, Bayelsa State

Home About IJBST For Authors Issues Useful Downloads Contact


FAQ OJBST

Questions are asked and these questions need answers. This is the reason why this page is created to enable us share few worries!

×
Archive | ISSUE: , Volume: Jan-Mar-2026

Schiff Base Metal Complexes: A New Frontier in the Search for Effective Antiseptic Agents


Author:Dueke-Eze, C. U., Fasina, T. M.

published date:2026-Jun-04

FULL TEXT in - | page 109 - 115

Abstract

The global increase in antimicrobial resistance has emphasized the urgent need for novel and effective antiseptic agents. This challenge has spurred interest in developing new chemical entities, including coordination compounds that can enhance antimicrobial efficacy and offer alternative strategies for infection control. In view of this growing antimicrobial challenge, isoniazid Schiff bases, namely N-(2-hydroxy-5-bromobenzylidene)isonictinoylhydrazide(L1) and N-(2-hydroxy methoxybenzylidene) isonictinoylhydrazide (L2), and their Cu(II) and Co(II) complexes are reported. The compounds were characterized based on melting point, FTIR, 1H and 13C NMR and elemental analysis. The Schiff bases act as tridentate ligands bonding through azomethine nitrogen, phenolic, and carbonyl oxygen atoms. The in vitro antibacterial study was performed on the compounds against Staphylococcus aureus ATCC 25923, Enterococcus feacalis ATCC 29212, Escherichia coli 2592 and Pseudomonas aeruginosa 27853. The Schiff base ligands and their complexes were observed to exhibit a strong inhibitory effect on S. aureus bacteria, with the cobalt complexes exhibiting the greatest effect. This implies that these compounds may be considered promising candidates for further exploration as potential antiseptic agents subject to future toxicological evaluation and formulation studies.

Keywords: Antibacterial activity, Isoniazid derivatives,,,

References

Adewumi, I .P. (2025).  Critical analysis of the infectious disease surveillance and response system in Nigeria. Discover Public Health 22, 272. https://doi.org/10.1186/s12982-025-00668-6

Ashbolt, N. J. (2015). Microbial contamination of drinking water and food: transmission routes and public health risks. Environmental Research, 140, 93–108.

Camellia, F. K., Ashrafuzzaman, M., Islam, M. N., Banu, L. A., and Kudrat-E-Zahan, M. (2022). Synthesis, Characterisation, Antibacterial and Antioxidant Studies of Isoniazid-based Schiff Base Ligands and Their Metal Complexes. Asian Journal of Applied Chemistry Research11(3), 8–23. DOI: https://doi.org/10.9734/ajacr/2022/v11i330257

Centres for Disease Control and Prevention (CDC). (2024). Foodborne Germs and Illness

Dueke-Eze, C. U. and Fasina, T. M. (2023). Schiff bases of salicyl diene-2-aminopyridine: Synthesis, Uv-Vis study and Antibacterial study, International Journal of Basic Science and Technology, 9(2), 85- 91, doi.org./55555/DHHP4380.

Hossain, Md-S., Mannan, Md-A., Camellia, F. K., Zaman, A. K. B. and Zakaria, C. M. (2017). Isoniazid Containing Metal-Based Drugs as Potential Antimicrobial Agents: A Short Review. Science Journal of Chemistry, 5(5), 62-70. DOI: https://doi.org/10.11648/j.sjc.20170505.11

Islam, M. B., Islam, M. I.,  Nath, N.,  Emran, T. B.; Rahman, M. R., Sharma, R. and Matin, M. M. (2023).  Recent Advances in Pyridine Scaffold: Focus on Chemistry, Synthesis, and Antibacterial Activities. Biomedical Research International, 18, 2023:9967591. DOI: 10.1155/2023/9967591

Islam, Md-A., Tasnim, F., Hossain, Md-S.  Hossen, Md. Kudrat-E Zahan, K-E. Md. and Ali Asraf, Md A. (2025). Experimental and computational insights into antibacterial and antioxidant properties of metal complexes with isoniazid-based Schiff base ligands,Journal of Molecular Structure, 1324, 140916.  DOI:10.1016/j.molstruc.2024.140916.

Jonah, J. H., Samuel, G., Abdullahi, M. I., Emmanuel, E. A.,  Danladi, S. S.,   Ekwuluo, C. E. (2024). Nigeria’s public health response to disease outbreaks: A review of strengths and weaknesses, Journal of Public Health in Africa, 15(1), 773 DOI: https://doi.org/10.4102/jphia.v15i1.773

Jorge J.,  Piino, D.,  Santos, K. F., Timóteo, F., Vasconcelos, R. R.P., Ayala, C. O. I., Granja, I. J.A., de Souza, D., Frizon, T. E. A.,  Vaccari, B.  G.; Braga, A. L., Saba, S., Rashid, H. U. and Rafique, J. (2024).  Recent Advances on the Antimicrobial Activities of Schiff Bases and their Metal Complexes: An Updated Overview. Current Medicinal Chemistry, 31(17):2330-2344. DOI: 10.2174/0929867330666230224092830.

Joseph, J., Nagashri, K. and Janaki, G.B. (2012). Novel metal-based antituberculosis agent: Synthesis, characterisation, catalytic and pharmacological activities of Copper complexes. European Journal of Medicinal  Chemistry, 49, 151-163.

Malav and Ray (2025). Recent advances in the synthesis and versatile applications of transition metal complexes featuring Schiff base ligands. RSC Advances, 15, 22889-22914

Marinescu, M. and Popa, C.-V. (2022). Pyridine Compounds with Antimicrobial and Antiviral Activities. International Journal of Molecular Sciences, 23, 5659

Matthew, A.;  Kumar, R.; Mazumder, A.;  Salahuddin and Bhadauria, H. (2023). Insights Into the Synthetic Strategies, Biological Activity, and Structure–Activity Relationship of Pyridine and Analogues: A Review, Letters in Organic Chemistry, 20,(11) DOI: https://doi.org/10.2174/1570178620666230525142927

Paswan, S., Jaiswal, N., Urvashi, Nath, A.,  Kumar, M., Mishra, D. and Yadav, N. (2026).  Emerging trends and structure–activity insights of Schiff base–metal complexes as antibacterial agents, RSC Advances, 16, 3478-3508. 

Suganya, M. and Puthilibai, G. (2024). Synthesis, Spectral Characterisation, Antibacterial and Anticancer Evaluation of Novel Isoniazid-based Schiff Base Ligand-derived Transition Metal Complexes. Asian Journal of Chemistry, 36(3), 579–585. DOI: .https://doi.org/10.14233/ajchem.2024.30955

Tarallo, M. B., Urquiola, C., Monge, A., Costa, B. P., Ribeiro, R. R., Costa-Filho, A.J., Mercader, R.  C., Pavan, F. R., Leite, C.Q-F., Torre, M. H. and Gambino, D. (2010). Design of novel Iron compounds as potential therapeutic agents against tuberculosis. Journal of  Inorganic Biochemistry,  104, 1164-1170.

The Guardian Nigeria (2025). Nigeria loses billions to healthcare-associated infections due to poor infection prevention and control

Valgas, S. M; De Souza, E. F. A; Smânia, E. F. A and Smânia, A. (2007). Screening methods to determine antibacterial activity of natural products. Brazil. Journal of Microbiology, 38: 369–380.

a World Health Organisation (WHO). (2025). Global antibiotic resistance surveillance report 2025. Geneva: WHO.

bWorld Health Organisation (WHO). (2025). WHO warns of widespread resistance to common antibiotics worldwide. Geneva: WHO.

World Health Organisation. (2015). Estimates of the global burden of foodborne diseases.

 

FULL TEXT in - | page 109 - 115

Issue Archive

Volume 13 2027

Volume 12 2026

Issue 2-Apr-Jun
Issue 1-Jan-Mar

Volume 11 2025

Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 2-Apr-Jun
Issue 1-Jan-Mar

Volume 10 2024

Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 2-Apr-Jun
Issue 1-Jan-Mar

Volume 9 2023

Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 2-Apr-Jun
Issue 1-Jan-Mar

Volume 8 2022

Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 2-Apr-Jun
Issue 1-Jan-Mar

Volume 7 2021

Issue 4-Oct-Dec
Issue 2-Apr-Jun
Issue 1-Jan-Mar

Volume 6 2020

Issue 4-Oct-Dec
Issue 3-Jul-Sep

Volume 5 2019

Issue 4-Oct-Dec
Issue 2-Apr-Jun
Issue 1-Jan-Mar

Volume 4 2018

Issue 4-Oct-Dec
Issue 3-Jul-Sep
Issue 2-Apr-Jun

Volume 3 2017

Issue 4-Oct-Dec
Issue 1-Jan-Mar

Volume 2 2016

Issue 4-Oct-Dec

Volume 1 2015

Issue 4-Oct-Dec


Copyright © International Journal of Basic Science and Technology | Faculty of Science, Federal University Otuoke 2019. All Rights Reserved.
P.M.B. 126, Yenagoa. Bayelsa state Nigeria