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International Journal of Basic Science and Technology

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Archive | ISSUE: , Volume: Jan-Mar-2026

Pyridine Based Schiff Bases as Promising Scaffolds for Antioxidant Drug Development


Author:Dueke-Eze, C.U.mFasina, T, M

published date:2026-Jun-10

FULL TEXT in - | page 29 - 37

Abstract

Pyridine-based heterocyclic compounds are well known for their various biological activities and possible impact on the antioxidant behaviour of organic molecules. In this study, four Schiff bases derived from 2-aminopyridine and substituted salicylaldehydes, namely salicylidene-2-aminopyridine (L1), 5-methoxy-salicylidene-2-aminopyridine (L2), 5-nitro-salicylidene-2-aminopyridine (L3), and 5-bromo-salicylidene-2-aminopyridine (L4), were evaluated for their in vitro antioxidant activity. The compounds were studied utilising melting point measurement, elemental analysis, infrared spectroscopy, and nuclear magnetic resonance spectroscopy. Their antioxidant activities were evaluated using DPPH radical scavenging, nitric oxide scavenging, ferric reducing antioxidant power, and total antioxidant capacity tests. The results demonstrated that the compounds' radical scavenging and reduction actions were concentration-dependent. Among the examined Schiff bases, the nitro-substituted derivative, L3, had the highest antioxidant efficacy across all testing. This better performance indicates that the nitro substituent increased the antioxidant capacity of the pyridine-based Schiff base. As a result, L3 could be a good candidate for future research into the development of effective antioxidants.

Keywords: Pyridine Schiff bases; 2-aminopyridine; antioxidant activity; ,,,,

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