Subacute Effects of Isoniazid (Inh) on The Kidney and Liver of Albino Mice

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Abstract

The subacute effects of Isoniazid on the kidney and liver were determined using twenty-five Albino white mice. The mice were sex- matched and grouped into 5 cages of five mice each. Lesser dose of the known LD50 of isoniazid graded into 0mg/kg, 10mg/kg, 20mg/kg, 40mg/kg and 60mg/kg were administered through their distilled water. They were exposed to water and Guinea feed© libitum for 49 days. Each mouse was weighed on day 1 and observed daily. On day 49, the final weights of the mice were measured and two mice were selected at random from each cage and sacrificed. Their kidney and lever were harvested, examined grossly and processed using standard histological techniques for light microscopy. The results revealed no significant weight change. Grossly, the organs showed brown induration. Microscopically, significant structural disorders of both organs were observed with the exception of the group administered with 10mg/kg. Speculatively these effects can be extrapolated to man, thus similar damage to human kidney and liver may be possible. Therefore, their administration should be carefully monitored

Keywords: Subacute, Isoniazid, 14 Kidney, Liver, Albino 15 Mice.

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