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×published date:2025-Aug-01
FULL TEXT in - | page 187 - 196
Abstract
Potassium bromate (KBrO3), a food additive and environmental contaminant, is a known neurotoxin whose deleterious effects are primarily mediated through the induction of oxidative stress. Elaeis guineensis (red palm oil) is a natural product exceptionally rich in antioxidants, including tocotrienols and carotenoids. This study was designed to investigate the potential neuroprotective effects of Elaeis guineensis fruit oil against the neurobiochemical toxicity induced by oral administration of potassium bromate in male Wistar rats. Twenty-four male Wistar rats were randomly divided into four groups (n=6): a control group, a group receiving potassium bromate (100 mg/kg) only, 2 groups pre-treated with Elaeis guineensis oil (2 ml/kg and 4ml/kg) prior to potassium bromate administration. Following a 21-day administration period, brain tissues were homogenized and analyzed for key biochemical markers, including glutathione (GSH), malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), acetylcholinesterase (AChE), and nitric oxide (NO). Administration of potassium bromate alone resulted in a statistically significant (p<0.05) decrease in the brain concentrations of GSH, CAT, SOD, and AChE, coupled with a significant elevation in MDA and NO levels when compared to the control group. However, pre-treatment with Elaeis guineensis fruit oil significantly ameliorated these adverse effects, restoring the measured biochemical parameters to levels comparable with the normal control group. The findings demonstrate that E. guineensis fruit oil possesses potent neuroprotective properties against potassium bromate-induced toxicity. This protective capacity is likely attributable to its strong free-radical scavenging and antioxidant activities, which mitigate oxidative neuronal damage.
Keywords: Neuroprotective Effects Elaeis guineensis Potassium Bromate Oxidative Stress,,,,
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