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Archive | ISSUE: , Volume: Apr-Jun-2024

Amelioration of Dyslipidaemia and Antioxidant Parameters in Alloxan Induced Diabetic Rats Treated with a Hydrazone Derived from 4 Aminoantipyrine and Butanedione, and its Ni(II) Complex.


Author:Agbo, N.J.; Ukoha, P.O.

published date:2024-May-15

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Abstract

Investigating the antioxidant and antihyperlipidemic properties of c[Ni(HL)2]Cl2 was the goal of this work. Diabetic rats induced with alloxan. After two days of a single intraperitoneal injection of Alloxan (140 mg/kg), diabetes in albino rats was verified. Oral glibenclamide (200 mg/kg) and HL and [Ni(HL)2]Cl2 (200 and 400 mg/kg, respectively) were given every day for 14 days. Rats that had fasted overnight were killed on the fifteenth day, and blood was drawn to measure total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and total glycerides (TG). In order to assess the in vivo antioxidant activity of HL and [Ni(HL)2]Cl2, anti-oxidants were homogenised, and lipid peroxidation assays (Malondialdehyde (MDA), glutathione (GSH), catalase (CAT), erythrocyte superoxide (SOD), and glutathione peroxidase (GPx) were conducted in rats treated with HL and [Ni(HL)2]Cl2 and control groups. When compared to the diabetic control group, HL and [Ni(HL)2]Cl2 at doses of 200 and 400 mg/kg shown significant improvements in MDA, GSH, CAT, GPx, and SOD and significant reductions in blood glucose and lipid profiles. We determined that HL and [Ni(HL)2]Cl2 exhibit antihyperlipidemic and potentials on total glycerides (TG) and cholesterol (TC)

Keywords: Alloxan, 4-aminoantipyrine, Butanedione, Diabetes, Dyslipidaemia

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