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International Journal of Basic Science and Technology

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Archive | ISSUE: , Volume: Apr-Jun-2023

Schiff bases of Salicyl diene 2 aminopyridine: Synthesis, Uv Vis study and Antibacterial Activity


Author:Dueke-Eze, C. U., Fasina, T. M.

published date:2023-Jun-10

FULL TEXT in - | page 85 - 91

Abstract

Despite tremendous advancements in drug research from laboratory to clinic, the need for new antibacterial agents is evident given the continued disease burden globally. In particular, Small compounds that are highly effective against both Gram-positive and Gram-negative bacteria are essential for therapeutic settings because they can simultaneously prevent and treat diseases caused by bacteria with a lower risk of developing resistance. Based on the aforementioned, Schiff bases derived from 2-aminopyridine and salicylaldehyde namely; salicylidene-2-aminopyrdine (L1), 5-methoxy-salicylidene-2-aminopyridine (L2), 5-nitro-salicylidene-2-aminopyridine (L3) and 5-bromo-salicylidene-2-aminiopyridine (L4) are reported for their in vitro antibacterial activity. The compounds were characterized by melting point, elemental analysis, IR, and NMR. The observed absorption band above 400 nm in DMF for L3 was attributed to keto-enol tautomerism following the electronic transitions carried out in 1,4-dioxane, ethanol, and N, N- dimethylformamide (DMF). In vitro screening of the compounds on Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC 25923), and Enterococcus feacalis (ATCC 29212) in 1,4-dioxane and N, N- dimethylformamide (DMF) was studied using disc diffusion method. The results indicate that the compounds can inhibit the growth of both Gram positive and Gram negative bacterial and can be considered as a broad-spectrum agent

Keywords: 2-aminopyridine, salicylaldehyde, In-vitro, Antibacterial activity,

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