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×published date:2023-Jun-10
FULL TEXT in - | page 85 - 91
Abstract
Despite tremendous advancements in drug research from laboratory to clinic, the need for new antibacterial agents is evident given the continued disease burden globally. In particular, Small compounds that are highly effective against both Gram-positive and Gram-negative bacteria are essential for therapeutic settings because they can simultaneously prevent and treat diseases caused by bacteria with a lower risk of developing resistance. Based on the aforementioned, Schiff bases derived from 2-aminopyridine and salicylaldehyde namely; salicylidene-2-aminopyrdine (L1), 5-methoxy-salicylidene-2-aminopyridine (L2), 5-nitro-salicylidene-2-aminopyridine (L3) and 5-bromo-salicylidene-2-aminiopyridine (L4) are reported for their in vitro antibacterial activity. The compounds were characterized by melting point, elemental analysis, IR, and NMR. The observed absorption band above 400 nm in DMF for L3 was attributed to keto-enol tautomerism following the electronic transitions carried out in 1,4-dioxane, ethanol, and N, N- dimethylformamide (DMF). In vitro screening of the compounds on Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC 25923), and Enterococcus feacalis (ATCC 29212) in 1,4-dioxane and N, N- dimethylformamide (DMF) was studied using disc diffusion method. The results indicate that the compounds can inhibit the growth of both Gram positive and Gram negative bacterial and can be considered as a broad-spectrum agent
Keywords: 2-aminopyridine, salicylaldehyde, In-vitro, Antibacterial activity,
Al-Atbi, H. S., Jaraf, H. A., and Sabti, A. B. (2022). Synthesis, Antibacterial, and Antioxidant Activities of Some Schiff Bases: Tropical Journal of Natural Product Research, 6(12), 1925–1929.
Ayad, M. M and Mansour, I. A. (1995). Spectroscopic and Conductometric Studies on some Schiff Bases. Montash. Chemistry, 126, 385-392.
Borase, J. N., Mahale, R. G., Rajput, S .S. (2021). Design, synthesis and biological evaluation of heterocyclic methyl substituted pyridine Schiff base transition metal complexes. SN Applied Sciences, 3, 197, https://doi.org/10.1007/s42452-021-04144-z
Catalano, A., Iacopetta D., Ceramella J., Scumaci D., Giuzio F., Saturnino C., Aquaro S., Rosano C., Sinicropi M.S. (2022). Multidrug resistance (MDR): A widespread phenomenon in pharmacological therapies, Molecule, 27(3), 616.
Cinarli ,A., Gürbüz1 , D., Aydin Tavman, A. and Birteksöz, S.A.(2011). synthesis, spectral characterizations and antimicrobial activity of some schiff bases of 4-chloro-2-aminophenol, Bulletin Chemical Society Ethiopia, 25(3), 407-417.
Dueke-Eze, C. U., Madueke, N. A., Iroha, N. B., Maduelosi, N. J., Nnanna, L. A., Anadebe, V. C. and Chokor, A. A. (2022). Adsorption and inhibition study of N-(5-methoxy-2-hydroxybenzylidene) Isonicotino- hydrazide Schiff base on copper corrosion in 3.5% NaCl, Egyptian Journal of Petroleum, 31 (2022) 31–37.
Dueke-Eze, C. U., Fasina, T. M., Oluwalana, A. E., Familoni, O. B., Mphalele, J. M. and Onubuogu, C. (2020). Synthesis and biological evaluation of copper and cobalt complexes of (5-substituted-salicylidene) isonicotinichydrazide derivatives as antitubercular agents, Scientific African, 9, e00522. https://doi.org/10.1016/j.sciaf.2020.e00522
Gür, M., Yerlikaya, Ş., Şener, N., Özkınalı, S., Baloglu, M., Gö, H., Celik-Altunoglu, Y., Demir, S. and Şener, İ. (2020). Antiproliferative-antimicrobial properties and structural analysis of newly synthesized Schiff bases derived from some 1,3,4-thiadiazole compounds. Journal of Molecular Structure. 1219. 128570. 10.1016/j.molstruc.2020.12857.
Gogoi, H. P., Singh, A., Pranjit Barman, P. and Diganta Choudhury, D. (2022). A new potential ONO Schiff-Base ligand and its Cu(II), Zn(II) and Cd(II) Complexes: Synthesis, structural Elucidation, theoretical and bioactivity studies, Inorganic Chemistry Communications, 146, 1387-7003
.https://doi.org/10.1016/j.inoche.2022.110153.
Hameed A., Al-Rashida M., Uroos M., Abid Ali S., Khan K.M. (2017). Schiff bases in medicinal chemistry: A patent review (2010-2015), Expert on Opinion. Therapeutic Targets, 27, 63–79. doi: 10.1080/13543776.2017.1252752.
Janowska, S., Khylyuk, D., Janowski, M.; Kosikowska, U., Strzyga-Łach, P., Struga, M. and Wujec, M. (2023). Synthesis and Biological Evaluation of New Schiff Bases Derived from 4-Amino-5-(3-fluorophenyl)-1,2,4-triazole-3-thione, Molecule, 28, 2718.
Joule, J. A., Mills, K. and Smith, G. F. (1995). Heterocyclic Chemistry. Chapman and Hall
London. 3rd edition; pp 516.
Jubeen, F. and Zafar, I. (2018). Eco-friendly synthesis of pyrimidines and its derivatives: A review on broad spectrum bioactive moiety with huge therapeutic profile. Synthetic Communications. 48. 1-25. 10.1080/00397911.2017.1408840.
Kaushik, S., Paliwal, S. K., Iyer, M. R. and Patil, V. M. (2023). Promising Schiff bases in antiviral drug design and discovery. Medicinal Chemistry Research, 10, 1–14. doi: 10.1007/s00044-023-03068-0.
Kenawy, El-R., Azaam, M. and Khattab, S. (2019). Synthesis and Antibacterial Activity of Schiff base Compounds Based on Poloxamine. Delta Journal of Science. 40. 10.21608/djs.2019.139205.
Mahmoud, W. A., Zainab M. Hassan, Z. M. and Russel W. Ali, R. W. (2020). Synthesis and spectral analysis of some metal complexes with mixed Schiff base ligands 1-[2-(2- Hydroxybenzyl lideneamino)ethyl]pyrrolidine-2,5-dione and (2-hydroxybenzalidine)glycine, Journal of Physics: Conference Series, DOI 10.1088/1742-6596/1660/1/01202
Noble, J., Broquier, M., Gregoire, G., Soorkia, S., Pino, G., Marceca, E., Dedonder-Lardeux, C. and Jouvet, C. (2018). Tautomerism and electronic spectroscopy of protonated 1- and 2-aminonaphthalene. Physical Chemistry Chemical Physics. 20. 10.1039/C8CP00218E
Oruma, S.U., Ukoha, P, Uzoewulu, C., Ndefo, J. C., Ugwuoke, S. C., Ukwueze, N. N., Eze, T.E., Ekowo, C. C., Eze, F. U., Chinaegbomkpa, U. V., Okafor, S. N. and Ezeorah, C. J. (2021). Synthesis, Biological and In Silico Studies of a Tripodal Schiff Base Derived from 2,4,6-Triamino-1,3,5-triazine and Its Trinuclear Dy(III), Er(III), and Gd(III) Salen Capped Complexes, Molecules, 26, 4379. https://doi.org/10.3390/molecules26144379.
Rana, K., Pandurangan A., Singh N. and Tiwari A.K. (2012). A systemic review of Schiff bases as an analgesic, anti-inflammatory. International Journal of Current Pharmaceutical Research, 4, 5–11.
Shanty, A. A., Philip, J. E., Sneha, E. J., Kurup, M. P., Balachandran, S. and Mohanan, V. P. (2017). Synthesis, characterization and biological studies of Schiff bases derived from heterocyclic moiety, Bioorganic Chemistry, 70, 67-73.
Soliman, A. A. (1997). Effect of solvents on the electronic absorption spectra of some salicylidene thio-Schiff bases. Spectrochim. Acta A., 53: 509-515
Vhanale, B., Kadam, D. and Shinde, A. (2022). Synthesis, spectral studies, antioxidant and antibacterial evaluation of aromatic nitro and halogenated tetradentate Schiff bases. Heliyon. 5, 8(6):e09650. doi: 10.1016/j.heliyon.2022.e09650.
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