Mixed Ligand Complexes with Acetaldehyde Thiosemicarbazone: Synthesis, Characterization and Antifungal Activity

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Abstract

Mixed ligand complexes with chlorides of copper(II) and iron(III) of general composition [M(L1)(L2)Cl2] were synthesized using acetaldehyde thiosemicarbazone, a derivative of thiourea as primary ligand and 2, 2'- bipyridine as secondary ligand. The compounds were structurally characterized by Elemental Analysis (EA), Fourier Transform Infrared (FT-IR), Nuclear Magnetic Resonance (1HNMR) and Electronic spectroscopies. The infrared spectra data showed that the chelating behaviour of the secondary ligand towards the transition metal ion is through the two pyrindyl nitrogen atoms, whereas the primary ligand indicated the involvement of thiolato sulphur and azomethine nitrogen atom. The electronic spectra results displayed the existence of d-d electronic only in the copper complex, other bands seen correspond to n→π* transition and intra-ligand charge transfer and confirmed the proposed structures. The results of the elemental analysis for the compounds were in good agreement with the theoretical values. The complexes are of 1:1:1 stoichiometry and are non-electrolytes in solution. The antifungal activities evaluated by the diameter of zone of inhibition in (mm) against Aspergillus niger, Penicillium chrysogenum, Rhizopus stolonifer and Candida albicans revealed that the copper complex has more activity than that of iron. The study however showed that complexation of the ligand with metal ion resulted in increased antifungal activity.

Keywords: Prostate Specific Antigen, Serum Calcium Levels, Type 2 diabetes, Adult Males, Benin Ci

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